You can do it with Forms http://office.microsoft.com/en-us/outlook-help/prevent-e-mail-message-recipients-from-using-reply-all-or-forward-HA001114224.aspx Some additional links about Outlook Forms http://office.microsoft.com/en-us/outlook-help/overview-of-forms-in-outlook-HA010165958.aspx http://office.microsoft.com/en-us/outlook-help/tutorial-creating-and-distributing-custom-forms-with-outlook-HA001210610.aspx http://support.microsoft.com/kb/146636 http://www.techrepublic.com/blog/10things/10-easy-steps-to-customizing-an-outlook-2010-form/2635 Or you can use a simple plugin from Microsoft Research http://research.microsoft.com/en-us/projects/researchdesktop/noreplyall.aspx Rating 4.33 out of 5